Clinical Epistemology · Demos

A working portfolio built on one epistemic discipline: a system must earn the right to make a recommendation through explicit, inspectable gates, and "I cannot determine this" is a first-class output, not a failure.

Demonstration only. Everything on these pages runs on synthetic patients and is a conceptual prototype. Nothing here is validated for clinical use.

Clinical frameworks and tools

Interactive demonstrations. Every one runs entirely in the browser on synthetic patients.

folder 01

CKD Care Orchestration Framework

The flagship demo: 18 synthetic CKD patients from early CKD to kidney failure, seven care categories, next-best-action logic, and an explicit answer to whether the last recommendation actually happened (and why not).

careorch.nephromatics.com
folder 01

CKD Timeline Viewer

Longitudinal case viewer: 140 encounters across 12 patients, 2015 to 2026, grouped by outcome (transplant, dialysis, conservative care).

careorchtimeline.nephromatics.com
folder 02

Hypertension Management Framework

Structured hypertension management demo, the sibling of the CKD orchestrator.

htn.nephromatics.com
folder 04

Complex Multi-Disease Framework

Fluid and volume triage across DIAL and CKD pathways. Companion pages: Case Explorer and How it works (the multi-agent view).

cmdf.nephromatics.com
folder 07

CRRF: The Nine Steps

Flow sheet for the Clinical Recommendation Readiness Framework, the nine gates a system passes before it earns the right to make a recommendation.

crrf.nephromatics.com
folder 14

CHF ICD-10-CM to SNOMED CT Crosswalk

Terminology crosswalk built on the NLM-licensed APIs (UMLS, RxNorm, SNOMED CT, LOINC, VSAC).

codes.nephromatics.com

Synthetic patients

The canonical cohort behind every demo. No real patient data anywhere on this site.

Patients

Synthetic Patient Library

Explorer for the 18-patient cohort: master record, timeline, labs, next-best-action snapshot, and dated ADT events.

patients.nephromatics.com
Patients

Fluid Scenario Explorer (Variation Set A)

Twenty-one fluid-management scenario variants, P001A through P021A.

patients.nephromatics.com/fluid-scenarios

Governance

How the portfolio lines up with external responsible-AI guidance.

folder 10

CHAI Risk Categorization Template

Reusable, in-browser-fillable governance front-matter (the birth certificate a framework completes before deployment). Print or save as PDF to retain; nothing is stored.

chai.nephromatics.com
folder 10

CHAI Alignment Crosswalk

Two-tier gating model: CHAI risk categorization (a system's right to be deployed) over the CRRF nine gates (an output's right to be spoken).

chai.nephromatics.com/crosswalk
folder 10

Worked Example: Care Orchestrator

Completed CHAI categorization of the CKD Care Orchestration Framework across all 19 modifiers, each rating tied to its mitigating CRRF gate.

chai.nephromatics.com/worked-example

Reference documents

Briefs, maps, and conceptual models. Read-only.

top level

Care Orchestration Portfolio: Executive Brief

One-view summary of the portfolio for leadership.

docs.nephromatics.com/portfolio-brief
top level

The Portfolio Map

The answer to "what is all of this?": every framework, corpus, and governance layer on one page.

docs.nephromatics.com/portfolio-map
folder 06

BRIDGE Protocol: One-Page Summary

Hospitalization-reconstruction heuristic for extracting a clean story from fragmented records.

docs.nephromatics.com/bridge-summary
folder 06

BRIDGE Protocol: Process Flow Sheet

Step-by-step flow for the BRIDGE reconstruction protocol.

docs.nephromatics.com/bridge-flow
folder 11

Knowledge Graph Engineering: Visual Map

Two coupled graphs (clinical world model plus epistemic overlay) and a decision-theory reasoning layer.

docs.nephromatics.com/kg-visual-map
folder 11

Knowledge Graph × ECIF

How the knowledge graph design fits the Enterprise Clinical Intelligence Framework.

docs.nephromatics.com/kg-ecif-convergence
folder 11

Review: A Survey of Agent Memory

Seven convergence points between the agent-memory literature and this portfolio's architecture.

docs.nephromatics.com/kg-agent-memory-review
folder 11

Knowledge Graph × Meta-Harness

The layer nobody optimized: where harness design meets clinical knowledge.

docs.nephromatics.com/kg-meta-harness
_reference

Encounters, Events, Illnesses and Episodes

A conceptual model for the units of clinical time that every framework here assumes.

docs.nephromatics.com/encounter-episode-model
_reference

Nephrology Workforce Analysis 2026–2035

Supply and demand outlook for the specialty over the next decade.

docs.nephromatics.com/nephrology-workforce